Modulatory activity of brazilian red propolis on chemically
induced dermal carcinogenesis
Acta Cir Bras, 2014 Feb;29(2):111-7
PURPOSE:
To evaluate modulatory effects of a hydroalcoholic extract
of Brazilian red propolis (HERP) on dermal carcinogenesis using a murine model.
METHODS:
The HERP was used at concentrations of 10, 50 and 100 mg/kg
(PROP10, PROP50 and PROP100, respectively) to modulate dermal carcinogenesis
induced by the application of 9,10-dimetil-1,2-benzatraceno (DMBA) on the backs
of animals.
RESULTS:
The chemical compounds identified in HERP included propyl
gallate, catechin, epicatechin and formononetin. PROP100 treatment resulted in
significantly decreased tumor multiplicity throughout the five weeks of tumor
promotion (p < 0.05), and this concentration also resulted in the highest
frequency of verrucous tumors (p < 0.05). All of the tumors that developed in
DMBA-treated animals were regarded as squamous cell carcinomas and were either
diagnosed as non-invasive verrucous carcinomas or invasive squamous cell
carcinomas (SCCs). The average score for malignancy was significantly lower in
the PROP100-treated group than the non-treated group (p < 0.05), but there was
no difference between the other groups (p>0.05).
CONCLUSION:
The oral administration of hydroalcoholic extract of
Brazilian red propolis at a dose of 100 mg/kg had a significant modulatory
effect on the formation, differentiation and progression of chemically induced
squamous cell carcinoma in a murine experimental model.
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