Potential pathway of anti-inflammatory effect by New Zealand
honeys
Int J Gen Med, 2014 Mar 5;7:149-58
The role of honey in wound healing continues to attract
worldwide attention. This study examines the anti-inflammatory effect of four
honeys on wound healing, to gauge its efficacy as a treatment option.
Isolated phenolics and crude extracts from manuka
(Leptospermum scoparium), kanuka (Kunzea ericoides), clover (Trifolium spp.),
and a manuka/kanuka blend of honeys were examined. Anti-inflammatory assays
were conducted in HEK-Blue™-2, HEK-Blue™-4, and nucleotide oligomerization
domain (NOD)2-Wild Type (NOD2-WT) cell lines, to assess the extent to which
honey treatment impacts on the inflammatory response and whether the effect was
pathway-specific.
Kanuka honey, and to a lesser extent manuka honey, produced
a powerful anti-inflammatory effect related to their phenolic content. The
effect was observed in HEK-Blue™-2 cells using the synthetic tripalmitoylated
lipopeptide Pam3CysSerLys4 (Pam3CSK4) ligand, suggesting that honey acts
specifically through the toll-like receptor (TLR)1/TLR2 signaling pathway. The
manuka/kanuka blend and clover honeys had no significant anti-inflammatory
effect in any cell line.
The research found that kanuka and manuka honeys have an
important role in modulating the inflammatory response associated with wound
healing, through a pathway-specific effect. The phenolic content of honey
correlates with its effectiveness, although the specific compounds involved
remain to be determined.
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