The protective role of bee honey against the toxic effect of
melamine in the male rat kidney
Toxicol Ind Health. 2014 Sep 25. pii: 0748233714551765
This study aimed to test the protective role of natural bee
honey against melamine toxicity in the kidney of male albino rats. The dietary
supplementation of melamine at a dose of 20,000 ppm for 28 days induced renal
dysfunction, as reflected by a significant increase in kidney function
parameters (urea, creatinine, and uric acid) and an increase in potassium
levels. In addition, a decrease in catalase and glutathione-S-transferase and
an increase in lipid peroxide in the kidney tissue homogenate were also observed.
Histological changes in the melamine-treated group revealed hyperplasia and
damage in kidney cells and the accumulation of melamine crystals in kidney
tissues. Honey treatment for 28 days in rats concurrently administered melamine
at a dose of 2.5 g/kg body weight for 28 days improved the kidney function,
increased antioxidant enzymes, and decreased lipid peroxide levels. The
morphology of the kidney cells of the melamine-fed rats was also improved as a
result of honey treatment. In conclusion, this study revealed that natural bee
honey protects the kidney against the adverse effects induced by melamine
toxicity in male albino rats.
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