Antibacterial Activity and Inhibition of Adherence of
Streptococcus mutans by Propolis Electrospun Fibers
AAPS PharmSciTech. 2014 Sep 23. [Epub ahead of print]
Mouth-dissolving fibers with antibacterial activity for the
oral cavity were prepared by an electrospinning technique. Propolis extract was
used as an active ingredient and polyvinylpyrrolidone (PVP) K90 as the polymer
matrix. The morphology and diameter of the fibers were characterized by
scanning electron microscopy. Antibacterial activity against Streptococcus
mutans and the inhibition of S. mutans adhesion on a smooth glass surface
during the biofilm formation were tested. Propolis, 5% (w/v), was combined with
a PVP K90 solution, 8% (w/v), with or without Tween 80 including flavor
additives and electrospun with an applied voltage of 15 kV. Uniform and smooth
fibers of propolis-PVP K90 were obtained.
The results showed that electrospun
fibers with propolis extract can dissolve and release the propolis in water.
Propolis-PVP electrospun fibers showed better antibacterial activity by
reduction of bacteria adhesion on a smooth glass surface when compared to some
commercial mouthwash products. These results indicated the potential of
electrospun fibers to be used as mouth-dissolving fibers for effective
antibacterial activity in the oral cavity.
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