Stimulatory Effect of Brazilian Propolis on Hair Growth
through Proliferation of Keratinocytes in Mice
J. Agric. Food Chem., Article ASAP
Propolis is a natural honeybee hive product with the
potential for use in the treatment of dermatological conditions, such as
cutaneous abrasions, burns, and acne. In this study, we investigated whether
propolis stimulates hair growth in mice.
Ethanol-extracted propolis, which contains various
physiologically active substances such as caffeic acid and kaempferol,
stimulated anagen induction in shaved back skin. Anagen induction occurred
without any detectable abnormalities in the shape of the hair follicles (HFs),
hair stem cells in the bulge, proliferating hair matrix keratinocytes in the
hair bulb, or localization of versican in the dermal papilla. Propolis
treatment also stimulated migration of hair matrix keratinocytes into the hair
shaft in HFs during late anagen in the depilated back skin.
Organotypic culture of skin containing anagen stage HFs
revealed significant stimulation of hair matrix keratinocyte proliferation by
propolis. Furthermore, propolis facilitated the proliferation of epidermal
keratinocytes. These results indicate that propolis stimulates hair growth by
inducing hair keratinocyte proliferation.
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