Potential protective effect of Tualang honey on BPA-induced
ovarian toxicity in prepubertal rat
Background
To investigate the potential protective effects of Tualang
honey against the toxicity effects induced by Bisphenol A (BPA) on pubertal
development of ovaries.
Methods
This study was conducted on pre-pubertal female Sprague
Dawley rats. Animals were divided into four groups (n = 8 in each group). Group
I was administered with vehicle 0.2 ml of corn oil (Sigma-Aldrich, USA) using
oral gavage daily for six weeks; these animals served as negative control (CO
group), Group II was administered with BPA suspended in corn oil at 10 mg/kg
body weight and served as positive control (PC group), Group III was
administered with 200 mg/kg body weight of Tualang honey 30 min before the
administration of BPA at 10 mg/kg (TH group) while Group IV was administered
with 200 mg/kg body weight of Tualang honey 30 min before the administration of
corn oil (THC group). Body weight of all animals were monitored weekly.
Results
The BPA-exposed animals exhibited disruption of their estrus
cycle, while those animals treated with BPA together with Tualang honey,
exhibited an improvement in percentage of normal estrous cycle. Their ovaries
had lower numbers of atretic follicles compared to the PC group but higher than
the CO group.
Conclusions
Tualang honey has a potential role in reducing BPA-induced
ovarian toxicity by reducing the morphological abnormalities of the ovarian
follicles and improving the normal estrous cycle.
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