Thursday, May 04, 2006

Propolis May Help Prevent Breast Cancer

Therapeutic Effect of Paclitaxel and Propolis on Lipid Peroxidation and Antioxidant System in 7,12 Dimethyl Benz(A)Anthracene-Induced Breast Cancer in Female Sprague Dawley Rats
Life Sciences, Volume 78, Issue 24 , 8 May 2006, Pages 2820-2825

Abstract: The effect of propolis along with paclitaxel on 7,12 dimethyl benz(a)anthracene (DMBA) induced experimental breast cancer was investigated in female Sprague Dawley rats…

Administration of paclitaxel and propolis effectively suppressed breast cancer, which is revealed by the decrease in the extent of lipid peroxidation (LPO) with concomitant increase in the activities of enzymic antioxidants (superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx)) and non-enzymic antioxidants (reduced glutathione (GSH), Vitamin C and Vitamin E) levels when compared to breast cancer-bearing animals treated with either paclitaxel or propolis alone.

From our results, we conclude that propolis is a potent antioxidant and, when given in combination with paclitaxel, offers maximum protection against DMBA induced mammary carcinogenesis.

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