Friday, March 15, 2013

Malaysian Tualang Honey May Help Boost Benefits of Tamoxifen in Treating Breast Cancer

Tualang Honey Promotes Apoptotic Cell Death Induced by Tamoxifen in Breast Cancer Cell Lines
Tualang honey (TH) is rich in flavonoids and phenolic acids and has significant anticancer activity against breast cancer cells comparable to the effect of tamoxifen (TAM), in vitro.
The current study evaluated the effects of TH when used in combination with TAM on MCF-7 and MDA-MB-231 cells. We observed that TH promoted the anticancer activity of TAM in both the estrogen receptor-(ER-)responsive and ER-nonresponsive human breast cancer cell lines. Flow cytometric analyses indicated accelerated apoptosis especially in MDA-MB-231 cells and with the involvement of caspase-3/7, -8 and -9 activation as shown by fluorescence microscopy. Depolarization of the mitochondrial membrane was also increased in both cell lines when TH was used in combination with TAM compared to TAM treatment alone.
TH may therefore be a potential adjuvant to be used with TAM for reducing the dose of TAM, hence, reducing TAM-induced adverse effects.

1 comment:

Unknown said...

Hi, Are you well?

I think you posted so effective content about of article Malaysian Tualang Honey May Help Boost Benefits of Tamoxifen in Treating Breast Cancer. Thanks for your informative posting. As I have Mojo risen is a quick doing pennis enhancement remedy that is developed to help a guy when he is in need. With a 20-minute keep quickly before seeing outcomes, this makes it amazingly quick. All of the substances in these tablets are of course 100% natural, and discovered all over the earth. Many natural herbs discovered all over the earth are known to be very attractive assisting men that experience from development problems. Unfortunately, the better-known substances are not being used in this complement, which will enhance a few problems in men at the durability of the item. It does have Hot Goat Marijuana, but men would like to see it also implement the very well-known and efficient factor.

A Billion Thanks Only For You.