Tuesday, January 28, 2014

French Propolis Extracts May Help Treat Alzheimer's Disease, Diabetes and Atherosclerosis

Chemical composition, antioxidant and anti-AGEs activities of a French poplar type propolis
J Agric Food Chem, 2014 Jan 20
Accumulation in tissues and serum of advanced glycation end-products (AGEs) plays an important role in pathologies such as Alzheimer's disease or, in the event of complications of diabetes, atherosclerosis or renal failure. Therefore there is a potential therapeutic interest in compounds able to lower intra and extracellular levels of AGEs. Among them, natural antioxidants (AO) with true anti-AGEs capabilities would represent good candidates for development.
The purpose of this study was to evaluate the AO and anti-AGEs potential of a propolis batch, then to identify the main compounds responsible for these effects. In vivo, protein glycation and oxidative stress are closely related. Thus AO and antiglycation activities were respectively evaluated using both DPPH and ORAC assays as well as a newly developed automated anti-AGEs test.
Several propolis extracts exhibited very good AO and anti-AGEs activities and a bio-guided fractionation allowed us to identify pinobanksin-3-acetate as the most active component.

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