Thursday, July 03, 2014

Anti-Cancer Propolis Component Synthesized

Total Synthesis of Propolisbenzofuran B
Chem Sci, 2014 May 1;5(5):1794-1798
The first total synthesis of propolisbenzofuran B, a bioactive natural product isolated from honeybee propolis resin, is reported. The convergent synthesis makes use of a silicon-tether controlled oxidative ketone-ketone cross-coupling and a novel benzofuran-generating cascade reaction to deliver the core structure of the natural product from readily prepared precursors…
Propolisbenzofuran B is a natural product found in Brazilian propolis, first isolated in 2000 by Banskota and co-workers. Initial biological testing determined that the compound had a cytotoxic effect on murine colon 26-L5 carcinoma and human HT-1080 fibrosarcoma cells…

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