The protective effect of propolis on rat ovary against ischemia-reperfusion injury: Immunohistochemical, biochemical and histopathological evaluations
Biomedicine & Pharmacotherapy
Volume 111, March 2019
BUY Concentrated Propolis in Veggie Capsules
Highlights
• Ischemia/reperfusion caused increases in cytokines and oxidative-DNA damage in ovary.
• Propolis reversed the biochemical and immunohistochemical parameters in ovarian.
• Propolis restored histopathological changes and reduction of antioxidant enzymes.
• Propolis decreased germ cell apoptosis, DNA and tissue injury, infalammation.
In conclusion, the above findings demonstrate that propolis exerted a protective effect against ovarian I/RI in rats, through the inhibition of oxidative stress, the suppression of inflammatory processes, downregulation of 8-OHdG formations and the inhibition of ovarian cell apoptosis.
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