Egyptian Bee Honey and Propolis for Recurrent Intractable Childhood Candidal Vulvovaginitis
2nd International Conference on the Medicinal Use of Honey
Kota Bharu, Malaysia, 13th - 16th January, 2010
Eman Abdelhafiz A. Abdelal1, Ahmed T. Abdelhafez
Department of Pediatrics, KSA Airline Medical Center, Jeddah, KSA
Asiut woman and maternity clinic, Department of Obstetrics and Gynecology, Suhaje University, Egypt
BACKGROUND: Recurrent childhood candidal vulvovaginitis is a difficult clinical problem. Egyptian propolis has strong in-vitro antifungal activity, including candida species. Egyptian bee honey is known of its powerful anti-inflammatory and antimicrobial actions. The work targeted to evaluate the in vivo effect of local application of Egyptian bee honey (ebh) and Egyptian propolis (ep) in cases of resistant recurrent childhood candidal vulvovaginitis.
METHODS: Sixty two female children ranging between 4 and 9 years age, with recurrent vulvovaginal candidiasis were treated using the ebh/ep mix. The mix was composed of ethanol extract of ep and egyptian trifolium-cotton honey. It was diluted in 200 ml of pre-boiled water and was used as twice daily external vulvovaginal lavage for 7 days. Besides, children were also let to set in ebh/ep filed basin twice daily for 10 minutes. This group was compared to another group of 70 children who received conventional antimycotic therapy (fluconazole, clotrimazole, itraconazole). The two groups were compared for symptomatic improvement, mycological cure, and rate of recurrence.
RESULTS: Ebh/ep use was associated with: 1) better symptom control (83%; 50.2%), 2) better mycological cure (74%; 35%), and, 3) much less rate of recurrent acute episodes (13%; 49%). No side effects were noted.
CONCLUSION: Ebh/ep is an effective treatment to for children with recurrent intractable candidal vulvovaginitis. This might be encouraging for further trials, and for formulating systemic ebh/ep preparations for this purpose.