Royal Jelly (Honey Bee) is a Potential Antioxidant Against Cadmium-Induced Genotoxicity and Oxidative Stress in Albino Mice
J Med Food, 2009 Dec;12(6):1286-92
Cadmium (Cd) is a highly toxic heavy metal that induces genotoxic damage in the body. Besides, Cd induces oxidative damage in various tissues by altering antioxidant defence enzymes system.
In this study, we investigated the protective role of royal jelly (RJ) on Cd-induced genotoxicity and oxidative stress in mice…
Oral administration of RJ at two doses (100 and 250 mg/kg of body weight) showed significant suppression of mutagenic effects of Cd. Moreover, Cd-induced oxidative damage caused a significant decrease in GSH level and a significant increase in MDA level in the liver and kidneys.
Treatment with two doses of RJ caused a significant recovery in antioxidant status of GSH and a significant inhibition of MDA production.
It could be concluded that RJ has a protective role against Cd-induced genotoxicity and oxidative stress in mice, due to its antioxidant effects.