J Med Food, 2012 Dec 20
The aim of this study was to evaluate the metabolic effects
of 12-week honey consumption on patients suffering from type 1 diabetes
mellitus (DM).
This was a randomized crossover clinical trial done in the
National Institute for Diabetes and Endocrinology, Cairo, Egypt. Twenty
patients of both sexes aged 4-18 years with type 1 DM and HbA1C < 10%
participated in the study. They were randomized into two equal groups (intervention
to control and control to intervention). The dietary intervention was 12-week
honey consumption in a dose of 0.5 mL/kg body weight per day.
The main outcome measures were serum glucose, lipids, and
C-peptide, and anthropometric measurements. None of participants were lost in
follow-up. The intervention resulted in significant decreases in subscapular
skin fold thickness, fasting serum glucose, total
cholesterol, serum triglycerides, and low-density lipoprotein, and significant increases in fasting C-peptide (FCP) and
2-h postprandial C-peptide (PCP). As possible long-term effects of
honey after its withdrawal, statistically significant reductions in midarm
circumference, triceps skin fold thickness, SSFT,
FSG, 2-h postprandial serum glucose, TG, and HbA1C, and significant increases in FCP and PCP were
observed.
This small clinical trial suggests that long-term
consumption of honey might have positive effects on the metabolic derangements
of type 1 DM.
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