A Review of Molecular Mechanisms of the Anti-Leukemic
Effects of Phenolic Compounds in Honey
Int J Mol Sci, 2012 Nov 15;13(11):15054-73
Hematologic malignancies constitute about 9% of all new
cases of cancers as reported via the GLOBOCAN series by International Agency
for Research on Cancer (IARC) in 2008. So far, the conventional therapeutic and
surgical approaches to cancer therapy have not been able to curtail the rising
incidence of cancers, including hematological malignancies, worldwide. The last
decade has witnessed great research interest in biological activities of
phenolic compounds that include anticancer, anti-oxidation and anti-inflammation,
among other things.
A large number of anticancer agents combat cancer through
cell cycle arrest, induction of apoptosis and differentiation, as well as
through inhibition of cell growth and proliferation, or a combination of two or
more of these mechanisms. Various phenolic compounds from different sources
have been reported to be promising anticancer agents by acting through one of
these mechanisms.
Honey, which has a long history of human consumption both
for medicinal and nutritional uses, contains a variety of phenolic compounds
such as flavonoids, phenolic acids, coumarins and tannins.
This paper presents a review on the molecular mechanisms of
the anti-leukemic activity of various phenolic compounds on cell cycle, cell
growth and proliferation and apoptosis, and it advocates that more studies
should be conducted to determine the potential role of honey in both
chemoprevention and chemotherapy in leukemia.
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