An Investigation of Optimum NLC-Sunscreen Formulation Using
Taguchi Analysis
Journal of Nanomaterials
Journal of Nanomaterials, Volume 2013 (2013), Article ID 463732, 10 pages
This study used three kinds of wax and three kinds of oil,
with fixed mixture ratio including UV-blocking materials of ethylhexyl
methoxycinnamate, oxybenzone, and avobenzone, and applied hot high-pressure
homogenization process to prepare nanolipid sunscreen formulations. The
measured particle size of the sunscreen formulations was 100~300 nm around PDI
of 0.2 having a moderate polydisperse system. The distribution of zeta
potential was −50 mV to −35 mV, showing a stable system. The UV light-absorbing
range of 9 groups of sunscreen formulations was 275 nm~380 nm ranging within
UVA and UVB. The rheological analysis found that the viscosity change is shear,
thinning exhibiting colloid behavior.
Taguchi analysis found that the optimum combinations are the
carnauba wax and the blackcurrant oil combination for crystallinity and the
beeswax and CPG oil for UV absorption. In addition, UV-blocking ability shows
that the SPF was 51.5 and PFA was three stars for SU9 formulation. Finally, the
effect of temperature on the properties of sunscreen formulations was also
explored.
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