Thursday, November 23, 2017

Propolis, Honey Component Shows Anti-Inflammatory, Anti0cancer, and Anti-Viral Activities

Chrysin: Sources, beneficial pharmacological activities, and molecular mechanism of action

Phytochemistry. 2017 Nov 18;145:187-196

In recent years, public and scientific interest in plant flavonoids has tremendously increased because of their postulated health benefits.

This review was mainly focuses on the flavone chrysin (5,7-dihydroxyflavone), which occurs naturally in many plants, honey, and propolis. A number of in vitro and in vivo studies have revealed the therapeutic effects of chrysin against various diseases.

In general, chrysin exhibits many biological activities and pharmacological effects, including antioxidant, anti-inflammatory, anticancer, and antiviral activities. Moreover, many studies have reported on the bioavailability of chrysin. Because of its compromised bioavailability and enhanced protein stability, chrysin solid lipid nanoparticle (SLN) synthesis avoids proteolytic degradation and sustained release of drug delivery.

To clarify the mechanism of action of chrysin, researchers have investigated the structural binding relationship of chrysin through the docking computation method.

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