Saturday, May 09, 2009

Newly-Identified Propolis Compound Shows Anti-Cancer, Antimicrobial Activity

Identification of a Bioactive Compound Isolated from Brazilian Propolis Type 6
Bioorganic & Medicinal Chemistry, Article in Press, Accepted Manuscript

A prenylated benzophenone, hyperibone A, was isolated from the hexane fraction of Brazilian propolis type 6. Its structure was determined by spectral analysis including 2D NMR.

This compound exhibited cytotoxic activity against HeLa tumor cells (IC50 = 0.1756 μM), strong antimicrobial activity (MIC range – 0.73– 6.6 μg/mL; MBC range – 2.92–106 μg/mL) against Streptococcus mutans, Streptococcus sobrinus, Streptococcus oralis, Staphylococcus aureus, and Actinomyces naeslundii, and the results of its cytotoxic and antimicrobial activities were considered good.

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