An Initial Investigation into the Anti-Inflammatory Activity
and Antioxidant Capacity of Alpha-Cyclodextrin-Complexed Manuka Honey
J Complement Integr Med, 2012 Sep 24;9(1):Article 25
The bioactive properties of Manuka honey are now well
recognised, but the nature of honey (a sticky, viscous fluid) can make it hard
to use as a health remedy.
A new technology using encapsulation of Manuka honey with
alpha-cyclodextrin molecules has been developed, creating a free-flowing powder
that can easily be added to foods and beverages, or tableted / made into
capsules for use in health.
In this study, we investigated for antioxidant and anti-inflammatory
activity. Antioxidant capacity of raw Manuka honeys and matched complexes was
measured using the CUPRAC method.
Results showed that the antioxidant activity of honey
decreased when complexed, this being directly related to dilution of the final product
with alpha-cyclodextrin. Anti-inflammatory activity was assessed by measuring
inhibition of neutrophil TNF-alpha secretion. Contradictory results were
produced, with both stimulation and inhibition of TNF-alpha being observed.
Data from this study indicate that the formation of
cyclodextrin-based complexes of Manuka honey may potentiate the
anti-inflammatory activity of honey, but this may differ depending on
methylglyoxal content and the presence of other factors.
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