Total monoamine oxidase (MAO) inhibition by chestnut honey,
pollen and propolis
Journal of Enzyme Inhibition and Medicinal Chemistry, October 2014, Vol. 29, No. 5 , Pages 690-694
Monoamine oxidase (MAO) inhibitors are generally used in the
treatment of depressive disorders and some neurodegenerative illnesses, such as
Parkinson’s disease and Alzheimer’s disease.
The aim of this preliminary study
was to investigate the MAO [MAO (E.C.1.4.3.4)] inhibiting effect of various
apitherapeutic products, such as chestnut honey, pollen and propolis. Extracts’
MAO inhibition was measured using peroxidase-linked spectrophotometric assay in
enzyme isolated from rat liver microsomes, and the values are expressed as the
inhibition concentration (IC50) causing 50% inhibition of MAO. The antioxidant
activity of the bee products was also determined in terms of total phenolic
content (TPC) and ferric reducing/antioxidant power in aquatic extracts.
All
samples exhibited substantial inhibition of MAO, propolis having the highest.
Inhibition was related to samples’ TPCs and antioxidant capacities. These
results show that bee products possess a sedative effect and may be effective
in protecting humans against depression and similar diseases.
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