Inhibitory effects of bee venom on Propionibacterium
acnes-induced inflammatory skin disease in an animal model
Int J Mol Med, 2014 Nov;34(5):1341-8
Propionibacterium acnes (P. acnes) is a major contributing
factor to the inflammatory component of acne. The many prescription medications
for acne allow for a large number of potential combination treatments. However,
several antibiotics, apart from their antibacterial effects, exert side‑effects, such as the suppression of host inflammatory responses.
Purified bee venom (BV) is a natural toxin produced by honeybees (Apis
mellifera L.). BV has been widely used as a traditional medicine for various
diseases.
In the present study, to
investigate the therapeutic effects of BV against P. acnes-induced inflammatory
skin disease, P. acnes was intradermally injected into the ears of mice. After
the injection, BV was applied to the skin surface of the right ear.
Histological observation revealed that P. acnes induced a considerable increase
in the number of infiltrated inflammatory cells. However, treatment with BV
markedly reduced these reactions compared with the P. acnes-injected mice not
treated with BV. Moreover, the expression levels of tumor necrosis factor
(TNF)-α, and interleukin (IL)-1β were significantly reduced in the BV-treated
mice compared with the untreated P. acnes-injected mice. In addition, treatment
with BV significantly inhibited Toll-like receptor (TLR)2 and CD14 expression
in P. acnes-injected tissue. The binding activity of nuclear factor-κB (NF-κB)
and activator protein (AP)-1 was markedly suppressed following treatment with
BV. The results from our study, using an animal model, indicate that BV exerts
an inhibitory effect on inflammatory skin diseases.
In conclusion, our data indicate that BV has potential for
use as an anti-acne agent and may be useful in the pharmaceutical and cosmetics
industries.
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