Investigation into the potential use of poly(vinyl
alcohol)/methylglyoxal fibres as antibacterial wound dressing components
J Biomater Appl. 2014 Oct 16
As problems of antibiotic resistance increase, a continuing
need for effective bioactive wound dressings is anticipated for the treatment
of infected chronic wounds. Naturally derived antibacterial agents, such as
Manuka honey, consist of a mixture of compounds, more than one of which can
influence antimicrobial potency. The non-peroxide bacteriostatic properties of
Manuka honey have been previously linked to the presence of methylglyoxal.
The
incorporation of methylglyoxal as a functional antibacterial additive during
fibre production was explored as a potential route for manufacturing wound
dressing components. Synthetic methylglyoxal and poly(vinyl alcohol) were
fabricated into webs of sub-micron fibres by means of electrostatic spinning of
an aqueous spinning solution. Composite fabrics were also produced by direct
deposition of the poly(vinyl alcohol)-methylglyoxal fibres onto a preformed
spunbonded nonwoven substrate. Attenuated total reflectance fourier transform
infrared and proton nuclear magnetic resonance spectroscopies confirmed the
presence of methylglyoxal within the resulting fibre structure.
The
antibacterial activity of the fibres was studied using strains of
Staphylococcus aureus and Escherichia coli. Strong antibacterial activity, as
well as diffusion of methylglyoxal from the fibres was observed at a
concentration of 1.55 mg/cm2.
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