Bee venom ameliorates compound 48/80-induced atopic
dermatitis-related symptoms
Int J Clin Exp Pathol, 2013 Nov 15;6(12):2896-903
Honeybee (Apis mellifera L.) venom (BV) has been
traditionally used for the treatment of pain and inflammatory diseases such as
itchy skin problems. However, the precise mechanism of BV in ameliorating the
scratching behavior is not fully understood.
OBJECTIVE:
In order to evaluate the effect of BV on atopic
dermatitis-related symptoms in mice, we used a mouse skin scratching model
induced by compound 48/80. The anti-itch effect of BV was investigated in a
compound 48/80-induced mouse scratching behavior model.
BALB/c mice were injected intraperitoneally with vehicle
(saline 0.9%) or BV (0.01 and 0.1 mg/kg). One hour after treatment, the animals
received a subcutaneous injection of compound 48/80. Intraperitoneal
administration of BV (0.01 and 0.1 mg/kg) attenuated compound 48/80-induced
scratching behaviors.
The anti-scratching behavior effect of BV was in
proportional to its vascular permeability effects. Treatment with BV also
inhibited the degranulation of mast cells and the production of pro-inflammatory
cytokines in compound 48/80-treated skin tissues.
According to these results, BV may improve atopic
dermatitis-related symptoms by inhibiting the mast cell degranulation and
pro-inflammatory cytokine expression.
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