Analgesic effects of mad honey (grayanotoxin) in mice models
of acute pain and painful diabetic neuropathy
Hum Exp Toxicol, February 2014 vol. 33
no. 2 130-135
Objectives: The aim of this experimental study was to
investigate the effects of mad honey (grayanotoxin, GTX), used in complementary
medicine for a variety of purposes besides being food, on pain thresholds in
normal mice as model for acute pain and diabetic mouse as model for neuropathic
pain.
Methods: Hind paw withdrawal pain threshold to thermal
stimulus was measured with a plantar analgesia meter in a mice model using
healthy intact animals for acute pain and streptozotocin-induced diabetic
animals for chronic neuropathic pain. Time and dose-dependent effects of
intraperitoneally (i.p.) administered GTX were investigated in both acute and
neuropathic pain.
Results: In the acute pain model, administration of GTX
caused a dose- and time-dependent marked increase in the pain latency values.
In diabetic mice, which had markedly increased threshold to pain, GTX (0.1
mg/kg, i.p.) restored the mean pain latencies by decreasing from the pre-GTX
treatment values of 3.2 ± 0.6 to 3.0 ± 0.9s at 10 min, 3.2 ± 0.6s at 20 min,
3.4 ± 0.6s at 30 min, 2.6 ± 0.5s at 60 min and 2.4 ± 0.6s (p < 0.05) at 100
min.
Conclusion: The results from this experimental study
indicate that GTX exhibits significant analgesic activity and has potential
benefits against painful diabetic neuropathy. This is compatible with the widespread
use of GTX containing mad honey for alleviating pain. Further studies involving
long-term applications are needed for a more decisive conclusion regarding the
usefulness of GTX as an analgesic, especially in the treatment of painful
neuropathy.
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