Inhibitory effect of a propolis on Di-n-Propyl Disulfide or
n-Hexyl salicilate-induced skin irritation, oxidative stress and inflammatory
responses in mice
Fitoterapia, 2013 Dec 23. pii: S0367-326X(13)00316-X
PURPOSE:
Thermal imaging has been utilized, both preclinically and
clinically, as a tool for assessing inflammation. Psoriasis is a chronic
inflammatory skin disease characterized by hyperkeratosis, dermal inflammatory
infiltrate and increased angiogenesis. The aim of the present study was to
assess usefulness of thermography in psoriatic lesion regression after
topically treatment with bee propolis, recognized as potent antioxidants and
anti-inflammatory agents.
METHODS:
We monitored the inflammation process induced by irritants
such as n-Hexyl salicilate (HXS) or Di-n-Propyl Disulfide (PPD by
hystopatological assement of skin, thermographic scanning, total number of
inflammatory cells in peritoneal cavity, differential analysis of cells in
peritoneal cavity, macrophage spreading index, haematological and biochemical
parameters, frequencies of micronucleated reticulocytes, lipid peroxidation and
glutathione assay in skin.
RESULTS:
Topically applied ethanolic extract of propolis (EEP) with
HXS or PPD reduced the lipid peroxidation in skin and total number of
inflammatory cells in skin and peritoneal cavity, functional activity of
macrophages, the number of micronuclei in mouse peripheral blood reticulocytes
and enzymatic activity of ALP and AST.
CONCLUSION:
These results demonstrate that topical application of EEP
may improve psoriatic-like skin lesions by suppressing functional activity of
macrophages and ROS production. Taken together, it is suggested that EEP can
safely be utilized in the prevention of psoriasis-related inflammatory changes
without causing any toxic effect.
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