Royal jelly prevents the progression of sarcopenia in aged
mice in vivo and in vitro
J Gerontol A Biol Sci Med Sci, 2013 Dec;68(12):1482-92
Sarcopenia is characterized by the age-related loss of
muscle mass and strength. One of the mechanisms of sarcopenia is the loss in
the function and number of muscle satellite cells. Royal jelly (RJ) is a health
food used worldwide. To obtain better digestion and absorption than RJ,
protease-treated RJ (pRJ) has been developed. RJ and pRJ have been suggested to
have potential pharmacological benefits such as prolonging the life span and
reducing fatigue. Because these effects may improve sarcopenia and the
functions of satellite cells, we examined the effects of RJ or pRJ treatment on
the skeletal muscles in an animal model using aged mice. In vivo, RJ/pRJ
treatment attenuated the decrease in the muscle weight and grip strength and
increased the regenerating capacity of injured muscles and the serum
insulin-like growth factor-1 levels compared with controls. In vitro, using
isolated satellite cells from aged mice, pRJ treatment increased the cell
proliferation rate, promoted cell differentiation, and activated Akt intracellular
signaling pathway compared with controls. These findings suggest that RJ/pRJ
treatment had a beneficial effect on age-related sarcopenia.
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