Biological Activity of Propolis-Honey Balm in the Treatment
of Experimentally-Evoked Burn Wounds
Molecules 2013, 18(11), 14397-14413
Medicines of biogenic origin with micro-organic,
regenerative and analgesic properties are becoming more and more significant in
the treatment of burn wounds. These properties are found in apitherapeutics
such as propolis and honey—products collected and processed by a honey bee.
Their effect on the course of the healing processes is multidirectional.
The aim of the study was a histopathological and biochemical
analysis of the processes of scar formation in experimentally evoked burn
wounds in white pigs treated with the 1% and 3% Sepropol balms containing
standardized extracts of propolis and honey. The results were compared with the
therapeutic effects obtained with dermazin cream (1% silver sulfadiazine). The
level of collagen was determined in the wounds treated with 1% and 3% Sepropol
and compared with the collagen level in healthy skin and wounds treated with
dermazin.
Granulation and regenerated epithelium formation times were
compared, with the 3% Sepropol being by far the most effective. The 3% Sepropol
also increased the collagen level to 116% with the control sub-groups scoring
between 80% and 98%. The results show the healing process of burn wounds in
pigs treated with the Sepropol balm starts earlier and has a faster course than
the standard dermazin therapy.
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