Wednesday, November 21, 2007

Honey and Royal Jelly May Help Block Infections

Pharma Investments, Ventures & Law Weekly, 11/25/2007

"Pseudomonas aeruginosa antibiotic resistance has led to the search of natural compounds, which would competitively block its fucose > fructose/mannose-binding lectin ( PA-IIL) that mediates its biofilm formation and adhesion to animal cells," researchers in Ramat Gan, Israel report.

"Such compounds were found in human milk ( HM) and avian egg whites (see also Life Sciences). The present research has revealed that honey and royal jelly ( RJ), which are assigned to protect beehive progeny and are applied for human infection therapy, match HM in PA-IIL blocking," wrote B. Lerrer and colleagues, Bar-Ilan University.

The researchers concluded: "The function of their fructose (higher in honey) and mannosylated glycoproteins (higher in RJ) as powerful decoys in PA-IIL neutralization is of ecological/biological importance and implementability for the antibacterial adhesion therapeutic strategy."…

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