![](https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgoPG-N0Cae8ssysFDBfK_I8e3Me8hyKhghhWXQnx9FU3bfWqBefSctDLooI7AMMiA2GejKxxL2Amj_Bi_4An-Rjis8T2cYsbTiEooUAtJ5LfGxpKucJn9DR4xLnfwY55O5Mobb/s400/200px-KynurenicAcid.png)
Planta Medica, 2007 Nov 12
KYNA, a Trp metabolite, shows neuroprotective activity against excitotoxic amino acids by antagonizing the NMDA receptor (glycine, glutamate). Here we report the identification of KYNA by a combination of ESI-MS/MS and 1D- and 2D-NMR analyses in honey varieties of arboreal origin.
KYNA are absent in single-flower honeys from herbal flowers. These different distribution patterns might possibly involve an indirect plant defence mechanism against fungal pathogens and herbivorous parasites, ever-present on wild trees.
The presence of KYNA in honey may explain its pain-relieving effects reported in the literature. The substance, acting in concert with honey flavonoids (COX-2 inhibitors), by antagonizing the NMDA receptor may contribute to the antinociceptive effect of honey.
Moreover, kynureninates, owing to their antimicrobial properties, can favour the successful outcome of wounds and burns.
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