Wednesday, January 16, 2008

Bioactive Fraction of Manuka Honey Identified

Isolation by HPLC and Characterisation of the Bioactive Fraction of New Zealand Manuka (Leptospermum Scoparium) Honey
Carbohydrate Research, Article in Press, Corrected Proof

Abstract: Using HPLC a fraction of New Zealand manuka honey has been isolated, which gives rise to the non-peroxide antibacterial activity. This fraction proved to be methylglyoxal, a highly reactive precursor in the formation of advanced glycation endproducts (AGEs).

Methylglyoxal concentrations in 49 manuka and 34 non-manuka honey samples were determined using a direct detection method and compared with values obtained using standard o-phenylenediamine derivatisation. Concentrations obtained using both the methods were similar and varied from 38 to 828 mg/kg.

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